Connecting the Dots to Find a Protein that Affects TauQ&A with Stanley Prusiner, M.D.
A variety of brain troubles can trigger tau to form tangles, leading to diseases like chronic traumatic encephalopathy (CTE) and Alzheimer’s. While working to develop much-needed animal models that mimic the tricky process, Dana Foundation grantee Stanley Prusiner, M.D., found another protein, sortilin, that appears to govern tau’s actions.
Tau-er of Power
Tau protein helps nerve cells in the brain maintain their function and structure. When tau turns toxic, replicates, and spreads, neurons misfire and die. If neuroscientists can pinpoint the reasons for toxicity, identify possible modified tau states, and find a way to block tau’s movement from cell to cell, then progress can be made in fighting any number of neurological disorders.