Targeting Mitochondrial Dysfunction in Neurodegenerative Disease
Some brain disorders are linked to problems with mitochondria, which power cells among other critical functions. Researchers find that improving their function and increasing their numbers might stem some diseases and reduce symptoms of others.
The Promise and the Reality of Stem-Cell Therapies for Neurodegenerative Diseases
Jonathan D. Glass, M.D., is leading a clinical trial testing the safety of using adult stem cells to treat patients with amyotrophic lateral sclerosis (ALS), a neurodegenerative disease that remains untreatable. This trial, along with others like it, is just the beginning of a time-intensive process necessary to determine whether the benefits of stem-cell treatments—if there prove to be any—outweigh the risks. See also Commentary on this article, by Vassilis E. Koliatsos, M.D., and Leyan Xu, M.D., Ph.D.