Principal Investigator/Program Director (Last, First, Middle): Szele, Francis
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Szele, Francis G., PhD
eRA COMMONS USER NAME
Department of Physiology, Anatomy and Genetics
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
FIELD OF STUDY
College of William and Mary, VA University of Pennsylvania, PA Harvard Medical School, MA
B.S. Ph.D. Postdoc
Biology Neurobiology Developmental Biology
. Positions and Honors.
1985 - 1987 Biologist, Laboratory of Clinical Science, NIMH, NIH, Bethesda, MD
1990 - 1994 Ph.D., Dept. of Pharmacology, Chesselet Laboratory, University of Pennsylvania, Philadelphia, PA
1994 – 1999 Postdoctoral Fellow, Cepko Laboratory, Department of Genetics, Harvard Medical School, Boston, MA
1999 – 2007 Assistant Professor, Dept. of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL
2007 – present University Lecturer, Department of Physiology, Anatomy and Genetics & Tutorial
Fellow, St. Anne’s College, University of Oxford, UK
2001 Searle Junior Fellow, Searle Center for Teaching Excellence, Northwestern University.
2002 Dept of Pediatrics Faculty Award for Extraordinary Contributions to the Dept’s Missions.
2004 Recepent of Bernard L. Mirkin Research Scholar Endowed Chair.
2008 Junior Pro-Proctor, University of Oxford.
. Selected peer-reviewed publications (in chronological order).
. and Pritchett D.B.: High affinity agonist binding to cloned 5-Hydroxytryptamine2 receptor is not sensitive to GTP analogs. Molecular Pharmacology 43: 915-920, 1993.
, Alexander C., and Chesselet M-F.: Expression of molecules associated with neuronal plasticity in the striatum after aspiration and thermocoagulatory lesions of the cerebral cortex in adult rats. Journal of Neuroscience 15: 4429-4448, 1995.
and Chesselet M-F.: Cortical lesions induce an increase in cell number and PSA-NCAM expression in the subventricular zone of adult rats. Journal of Comparative Neurology 368: 439-454, 1996.
and Cepko C.L.: A subset of clones in the chick telencephalon arranged in rostrocaudal arrays.
urrent Biology 6: 1685-1690, 1996.
. and Cepko C.L.: The dispersion of clonally related cells in the developing chick telencephalon.
evelopmental Biology 195: 100-113, 1998.
Goings G.E., Wibisono B.L., and Szele F.G.: Cerebral cortex lesions decrease the number of BrdU-positive subventricular zone cells in mice. Neurosci. Lett. 329: 161-164, 2002.
Goings G.E., Sahni V., and Szele F.G.: Migration patterns of subventricular zone cells in adult mice change after cerebral cortex injury. Brain Res. 996: 213-226, 2004.
Sundholm-Peters N.L., Yang H.K.C., Goings G.E., Walker A.S., and Szele F.G.: Radial glia-like cells at the base of the lateral ventricles in adult mice. J. Neurocytol. 33: 153-164, 2004.
Yang H.K.C., Sundholm-Peters N.L., Goings G.E., Walker A.S., Hyland K., and Szele F.G.: Distribution of doublecortin expressing cells near the lateral ventricles in the adult mouse brain.
. Neurosci. Res. 76: 282-295, 2004.
Ramaswamy S., Goings G.E., Soderstrom K.E., Szele F.G., Kozlowski D.A.: Cellular proliferation and migration following a controlled cortical impact in the mouse. Brain Res. 1053: 38-53, 2005.
Sundholm-Peters N.L., Yang H.K.C., Goings G.E., Walker A.S., and Szele F.G.: Subventricular zone neuroblasts emigrate towards cortical lesions. J. Neuropath. Exp. Neurol. 64:1089-1100, 2005.
Gwendolyn E. Goings, Dorothy A. Kozlowski, and Szele F.G. Differential activation of microglia in neurogenic versus non-neurogenic regions of the forebrain. Glia, 54: 329-342, 2006.
Maria L.V. Dizon, Laura Shin, Nikki L. Sundholm-Peters, Edward Kang, and Szele F.G. Subventricular zone cells remain stable in vitro after brain injury. Neuroscience, 142: 717-725, 2006.
Ocbina, P.J., L. Shin, M.L. Dizon, and Szele F.G., Doublecortin is necessary for the migration of adult subventricular zone cells from neurospheres. Molecular and Cellular Neuroscience, 33: 126-135, 2006.
Nam S.C., Kim Y., Dryanovski D., Walker A., Goings G., Woolfrey K., Kang S.S., Chu C., Chenn A., Erdelyi F., Szabo G., Hockberger P., Szele F.G. Dynamic features of postnatal subventricular zone cell motility: A two- photon time-lapse study. J Comp Neurol 505:190-208, 2007.
Goings G. E., Greisman A., James R., Abram L., Smith-Begolka W., Miller S.D. and Szele F.G. Hematopoietic cell activation in the subventricular zone after Theiler’s virus infection. J. Neuroinflammation. 5: 44-66. 2008.
Kim Y., Comte I., Szabo G., Hockberger P. and Szele F.G. Adult mouse subventricular zone stem and progenitor cells are sessile and epidermal growth factor receptor negatively regulates neuroblast migration. PloS One 4: 8122-8135, 2009.
Kim Y., Wang W-Z., Comte I., Pastrana E., Tran P.B., Brown J., Miller R.J., Doetsch F., Molnár Z. and Szele F.G. Dopamine stimulation of postnatal murine subventricular zone neurogenesis via the D3 receptor. J. Neurochem. 114: 750-760, 2010.
Martinez-Molina N., Kim Y., Hockberger P. and Szele F.G< Rostral Migratory Stream Neuroblasts Turn and
Change Directions in Stereotypic Patterns. Cell Adhes and Migrat 5: 83-95 2011.
Comte I., Kim Y., Young C.C., van der Harg J.M., Hockberger P., Bolam P.J., Poirier F. and Szele F.G.
Galectin-3 maintains cell motility from the subventricular zone to the olfactory bulb. J Cell Sci In Press 2011.
C. Research Support
Previous Research Support
2001 – 2006 “Response of the Subventricular Zone to Brain Injury” R01 NS042253-04, NIH, NINDS Role: PI $600,000.
2002 – 2006 “Imaging Subventricular Zone Cell Migration With Time-Lapse Multiphoton Microscopy” CMRC Seed Grant , Internal; State of Illinois Excellence in Academic Medicine Role: PI $34,000.
2005 – 2006 “Subventricular Zone (SVZ) to Brain Injury Response” CMRC Bridge Grant Institutional Award. Role: PI $100,000.
2006 - 2008 “Are there stem cells in the adult brain?” Illinois Regenerative Medicine Institute, Role: Co-PI. $85,978.
2007 - 2010 “Two photon time-lapse microscopy of subventricular zone stem cell migration”. John
Fell Research Fund, University of Oxford. Role: PI. £93,857.
2008 - 2009 “MRI of subependymal zone stem cells in traumatic brain injury” Oxford Stem Cells
Institute. Role: PI. £10,000.
2008 to 2009 “Imaging cellular and molecular processes driving cell migration during development” BBSRC Research Equipment Initiative Grant Role: Co-PI. £237,000.
2009 - 2010 Wellcome Trust Value in People. Role: PI. £35,000.
Ongoing Research Support
2006 – 2011 “Subventricular zone cell migration after injury”NIH, NINDS, RO1 NS051594-01
Role: PI, $1,125,000.
2010 - 2011 “iPS cells from schzophrenics to probe neural development.” Oxford Stem Cells
Institute. Role: PI. £10,000.
2010 - 2011 “Adult Subventricular Zone Neurogenesis in Preclinical Models of Schizophrenia’.
Oxford University/McGill University Collaborative Award. Role: Co-PI £8,000.
Pending Research Support
2011 – 2012 “Increasing endogenous dopaminergic neurogenesis for Parkinson’s disease”Parkinson’s UK Innovation Grant. Role: PI. £35,000