Previous Grantees

Neurological Intensive Care Unit Multimodal Monitoring Project

by Stephan Mayer, M.D.

The investigators plan to develop integrated computerized monitoring software for use in the Intensive Care Unit (ICU). Working with ICU physicians, about sixty stroke patients seen in the ICU will be assessed initially and monitored. The clinical re...
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Mending the Brain, Minding Our Ethics

by Nicholas Schiff, M.D.

The researchers are currently studying a patient who, after years of being in a minimally conscious state, recently emerged from this state and has regained some of his communication abilities. Under the proposed Dana grant, the researchers plan to c...
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Improving the Accuracy and Efficiency of Surgical Implantation of Therapeutic DBS Electrodes: Intra-operative Use of Local Field Potentials to Indentify the Subthalamic Nucleus

by Peter Brown, M.A., M.D., F.R.C.P.

Researchers will undertake initial clinical studies of two new techniques for determining more precisely where electrodes should be surgically placed to produce effective deep brain stimulation for patients with Parkinson's disease. If the pilot and ...
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In Vivo Amyloid Measures in Mild Cognitive Impairment: 3-Site Stability Study

by Chester A. Mathis, Ph.D.

Investigators from the three institutions will undertake a three-step study to determine whether PET-PIB imaging can reliably detect the presence and distribution of brain amyloid in people. Researchers at each institution will enroll five cognitivel...
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Cognitive Neurophysiology Consortium: Direct Recordings from the Human Brain

by Itzhak Fried, M.D., Ph.D.

This two-phase consortium study by translational research neurosurgeons at UCLA and the Universities of Iowa and Toronto, working with select cognitive neuroscientists worldwide, will launch a broad investigation of the neuronal underpinnings of cogn...
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Deep Brain Stimulation for Treatment-Resistant Depression

by Helen Mayberg, M.D.

Dana funding will help support a study of deep brain stimulation (DBS) in patients with severe depression whose symptoms are not alleviated by conventional therapies.  The initial DBS clinical investigation by Dr. Mayberg and colleagues at the Univer...
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Aging-Related Cell Loss in the Sleep Switch

by Clifford B. Saper, M.D., Ph.D.

Investigators will determine whether sleep problems in a homogeneous group of older adults are associated with the loss of cells in a particular area of the brain.  If so, the results may lead to new methods to diminish sleep problems in adults and p...
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Novel Therapy of Acute Ischemic Stroke Using Selective Endovascular Brain Cooling Under MR Guidance

by John Pile-Spellman, M.D.

Researchers plan to test whether directly cooling the area of the brain that is at risk of further damage following a stroke, can provide protection against injury. The brain area would be cooled by injecting a cold solution through the artery supply...
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Blood Brain Marker Development for Prognosis in Recovery from Stroke

by Rajiv R. Ratan, M.D., Ph.D.

A team of investigators will determine whether any of several biologic factors may help to predict patients’ recovery from ischemic stroke.  These are strokes that result from lack of adequate blood flow to the brain due to a blood clot. Identifying ...
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Regulation of Inflammatory Responses by Vagus Nerve Stimulation in Patients with Rheumatoid Arthritis

by Kevin Tracey, M.D.

Researchers plan to determine whether an externally applied deep brain stimulator can control the activity of the vagus nerve to reduce painful inflammation and improve outcomes in patients with intractable autoimmune rheumatoid arthritis.   Only re...
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Neural Substrates of Musical Creativity

by Charles Limb, M.D.

Investigators will undertake fMRI imaging in jazz musicians as they create musical improvisations to examine whether the brain areas and processes that give rise to creative behavior are identifiable, consistent, and concrete. Neuroscientists know li...
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Molecular mechanisms underlying mood stabilization in bipolar disorder

by Evaristus A. Nwulia, M.D., MHS

Through this pilot study, investigators will determine the feasibility of identifying molecular targets of the mood-stabilizing drug lithium in acutely ill patients with bi-polar disorder which may serve as biomarkers for testing potential new drugs....
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Characterizing Effects of Deep Brain Stimulation on Medial Frontal and Cingulate Oscillations in Treatment Resistant Depression

by Helen S. Mayberg, M.D.

Researchers will explore the physiological basis for positive benefits in patients with intractable depression from  deep brain stimulation (DBS).Clinical studies conducted by Emory University investigators using DBS to treat severe depression that i...
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Evaluating Small Arteries in the Brain: The Effects of Hypertension and Diabetes

by Guy M. McKhann, M.D.

Investigators will conduct pilot tests in patients to determine whether a new imaging technique can help to differentiate brain signs of cognitive impairment and dementia associated with Alzheimer’s disease from those associated with underlying vascu...
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Determining the status of small arteries (the microvasculature of the brain

by Guy M. McKhann, M.D.

This study will assess whether the risk of stroke following a non-surgical catheter-based approach to replacing the aortic valve in older patients is associated with the procedure or with patients’ underlying vascular risk factors.   The aortic valve...
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Testing a Potential Treatment for Amyotrophic Lateral Sclerosis (ALS)

by Raymond P. Roos, M.D.

Investigators will determine whether a drug that is approved an on the market to treat another condition holds promise for treating fatal Amyotrophic Lateral Sclerosis (ALS).  ALS is a progressive and ultimately fatal disease resulting from the death...
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Adult Neurogenesis in Neuropsychiatric Disease

by Francis Szele

Investigators will study whether excessive development and altered migration of new neurons in the brain contributes to schizophrenia and to other psychiatric disorders.            Scientists have established that the brain continues to make new neur...
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Mending the Brain, Minding Our Ethics [folloq-on study]

by Nicholas D. Schiff, M.D.

The researchers are currently studying a patient who, after years of being in a minimally conscious state, recently emerged from this state and has regained some of his communication abilities.  Under the proposed Dana grant, the researchers plan to ...
Read more >

Neurological Intensive Care Unit Multimodal Monitoring Project

by Stephan Mayer, M.D.

The investigators plan to develop this integrated computerized monitoring software for use in the ICU.  Working with ICU physicians, about sixty stroke patients seen in the ICU will be assessed initially and monitored.  The clinical researchers will ...
Read more >

Assessing outcomes of interventions based on brain monitoring of comatose patients

by Stephan Mayer, M.D.

This study will begin to determine whether intensive care interventions that are undertaken in comatose brain-injured patients in response to several interrelated physiologic and metabolic factors that are constantly monitored in the brain are correl...
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Next generation electrical brain stimulation may help to restore memory deficits

by Michael Kahana

Researchers will work to refine and test the next generation of implanted and electrically stimulated brain electrodes, which are designed to help cognitively impaired patients regain their abilities to store and retrieve memories. The investigators ...
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Mitochondrial ND5 Mutations in Idiopathic Parkinson's disease

by W. Davis Parker, Jr., M.D.

Scientists still do not know what causes Parkinson’s disease (PD), the progressive degenerative brain disease produced by the death of neurons that use the neurotransmitter dopamine to communicate. Diagnosing PD in symptomatic patients, and different...
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Depot versus Oral Naltrexone Treatment of Opioid-Dependent Parolees

by Charles O'Brien, M.D., Ph.D

Nearly one-third of the U.S. prison population has a history of heroin addiction.  In March 2006, the directors of the Dana Foundation awarded a two-year $300,000 grant to the University of Pennsylvania to lead a five-site consortium pilot study to a...
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$90,000 for Neurological Outcomes After Coronary Artery Bypass Surgery [continuation grant]

by Guy McKhann, M.D.

A longitudinal study by Johns Hopkins’ cardiac surgeons, cardiologists, and neurologists, led by Guy M. McKhann, M.D., was initiated 13 years ago to determine whether coronary artery bypass graft surgery causes cognitive decline in patients, as repor...
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