by Emad N. Eskandar, M.D.
This neurosurgical research team will explore, at the neuronal level, how two brain networks normally drive the balance between safe and risky decision-making behaviors, and use the findings to design deep brain stimulation (DBS) strategies for modif...Read more >
by Michael L. Lipton, M.D., Ph.D.
Investigators will use diffusion tensor imaging (DTI), cognitive testing and gene studies to determine levels of sub-concussive head injury from soccer “heading” that increase the risk for adverse brain and cognitive functioning, and identify factors...Read more >
by Michelle Bradbury, M.D., Ph.D.
Researchers will undertake studies in cancer patients and animal models to determine whether a PET imaging agent effectively carries and delivers a drug treatment for fighting metastatic cancers in the brain.
The two most common metastatic cancers i...Read more >
by Christopher Smyser, M.D.
Investigators will determine whether a new type of imaging, Functional Connectivity MRI, can effectively identify pre-term infants with injuries to the brain’s white matter (communication cables) that place them at greatest risk of developing cerebra...Read more >
by Jordan Jacobelli, Ph.D
Investigators will use real-time fluorescent multi-photon microscopy imaging in a mouse model of multiple sclerosis to define the routes that autoimmune T cells use to enter the brain and spinal cord and attack the myelin sheaths that insulate nerve...Read more >
by Francis E. Lotrich, M.D., Ph.D.
Investigators will use BOLD fMRI and “arterial spin labeling” to explore how neural transmission of serotonin is altered in people who develop major depressive disorder in the presence of inflammation, and to identify factors that may determine pre-e...Read more >
by Chris Abbott, M.D., M.S.
This study will employ resting state fMRI to determine how electroconvulsive therapy exerts a therapeutic effect in patients with major depressive disorder, and to identify biomarkers that predict which patients are likely to relapse following ECT tr...Read more >
by Roy Hamilton, M.D.
This Phase II study will investigate whether responses by aphasia patients to a form of non-invasive brain stimulation, called transcranial magnetic stimulation, predict their capacity for brain plasticity and recovery of language and motor function....Read more >
by Roy Hamilton, M.D.
Researchers will undertake Phase I of a planned two-phase study to determine whether responses by aphasic stroke patients to a form of non-invasive brain stimulation, called transcranial magnetic stimulation, predict their capacity for brain plastici...Read more >
by Xin Jin, Ph.D.
This cellular imaging study in the Parkinson’s disease animal model will explore which of two hypothesized neural signaling problems is responsible for loss of voluntary motor control. People with Parkinson’s disease (PD) develop a characteristic gai...Read more >
by Peter de Blank, M.D., MSCE
This first phase of a planned two-phase study will determine whether it is feasible to use two imaging techniques in very young children with optic glioma. If feasible, the investigators propose a second phase to determine if the combined i...Read more >
by Jonathan Peelle, Ph.D.
This study will investigate how common age-related hearing loss changes brain structure and function, and what consequences these neurobiological effects have on understanding and remembering speech.
Behind only arthritis and hypertension, hearing l...Read more >
by Jong Yoon, M.D.
This study will examine whether high dopamine levels, as measured by high resolution fMRI, correlates with the onset of psychosis in schizophrenia and can serve as a diagnostic and therapeutic biomarker.
The prognosis for schizophrenia is poor. No...Read more >
by Andy Shih, Ph.D.
Through studies in mice, researchers will seek to improve MRI detection of tiny blockages in the brain’s small blood vessels that can lead to vascular dementia. Their findings may help clinicians identify at-risk patients and implement early preventi...Read more >
by Mary-Frances O'Connor, Ph.D.
will use fMRI imaging and other measures in 40 adults whose spouses have
recently passed away to determine whether an oxytocin nose spray reverses signs
of complicated (intense) grief and therefore might lead to an effective
treatmen...Read more >
by Brian Berman, M.D., M.S.
will combine PET and fMRI imaging in patients with cervical dystonia to see if
deficits in the neurotransmitter GABA alter the brain’s sensorimotor circuit to
produce the disorder’s characteristic involuntary muscle contractions that
...Read more >
by Scott Slotnick, Ph.D.
techniques in patients and healthy volunteers may identify a biomarker for
diagnosing and assessing treatments for frontal lobe diseases and injuries that
produce visual memory problems, such as Alzheimer’s and other dementing
diseases, ...Read more >
by Robert J. Young, M.D. and Ingo K Mellinghoff, M.D.
Investigators will advance a new MR
spectroscopy (MRS) imaging technique in patients to provide fast and reliable
indicators of deadly brain tumor progression and response to experimental
treatments.Brain tumors may be malignant or
benign. Malign...Read more >
by Nim Tottenham, Ph.D.
Investigators will correlate MRI brain
imaging with studies of stress-related gene alterations and anxiety behaviors
to explore how early life stress may influence brain development and then
mental health years later.Prior animal and human studie...Read more >
by Ragy Girgis, M.D.
This research is designed to
determine whether MRS imaging (Magnetic Resonance Spectroscopy) can assess the
effects of experimental therapies in increasing glutamate levels to treat
schizophrenia. Currently schizophrenia is
treated with antipsy...Read more >
by Susan Schwab, Ph.D.
Investigators anticipate that
cellular imaging techniques in a multiple sclerosis mouse model will enable
them to identify the signaling that drives immune cell infiltration and
inflammation in autoimmune multiple sclerosis (MS) and assess whethe...Read more >
by Mikhail Shapiro, Ph.D.
The ultimate goal of this
planned two-phase study is to use a novel MRI imaging agent to show, in living
laboratory mice, how brain inflammation occurs and damages cells following
brain injury. Phase I will establish the imaging approach’s feasib...Read more >
by Conor Liston, M.D., Ph.D.
Researchers will use functional
magnetic resonance imaging (fMRI) techniques in patients with major depressive
disorder (MDD) to try to identify atypical connectivity patterns in the brain that
are biomarkers for diagnosing MDD and for predicting...Read more >
by Vikram Chib, Ph.D.
will undertake Phase I of a planned two-phase study to ultimately determine
whether a non-invasive brain stimulation technique helps schizophrenia patients
learn from positive rewards and reduce the “negative” symptoms that
character...Read more >
by Sarkis K. Mazmanian, Ph.D.
The long vagal nerve transmits signals
between the brain and the gut. The evolutionally ancient gut microbial systemis
made up of 100 trillion bacterial
cellscomprised of more than 1,000
species that live in symbiosis with
thehuman and non-huma...Read more >
by Anthony Wagner, Ph.D.
Investigators will use high-powered
MRI imaging in older adults to see whether thinning of a tiny ribbon of tissue
in the brain’s hippocampus is a biomarker for pre-symptomatic Alzheimer’s
disease (AD) and can be used for screening and early dete...Read more >
by Christine DeLorenzo, Ph.D.
soon may be able to use a type of MRI imaging, called diffusion spectrum
imaging, to predict whether an individual patient with depression is likely to
respond to treatment with the class of antidepressants called SSRIs (selectiv...Read more >